Researchers at Technical University of Munich (TUM) have made a significant breakthrough in preventing Alzheimer’s disease with a novel therapeutic approach.
Targeting Harmful Molecules
The team developed a protein drug, H1GA, that targets amyloid beta biomolecules responsible for early-stage hyperactivity of nerve cells.
Remarkable Results in Animal Trials
Tests on mice showed:
- Suppressed neuronal hyperactivity.
- Repaired neuronal dysfunctions.
- Clearer positive effects compared to similar treatments.
Expert Insights
“We are still far from human therapy, but animal experiment results are encouraging… Completely suppressing neuronal hyperactivity is remarkable.” – Dr. Benedikt Zott
The Need for Effective Treatment
55 million people worldwide live with dementia, mostly Alzheimer’s.
10 million new cases diagnosed annually.
Current medications only treat symptoms, not underlying mechanisms.
Next Steps
- Developing more effective administration methods.
- Conducting human trials to confirm efficacy.
Reference
“β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer’s Disease” (Nature Communications, July 2024)
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