Victoria AdolphusA groundbreaking study conducted by researchers at Università Cattolica in Rome and the Fondazione Policlinico Universitario Agostino Gemelli IRCCS has shed new light on the mechanisms underlying Alzheimer’s disease. The study has identified a potential new therapeutic approach that could prevent cognitive decline and brain damage associated with the disease.
The Role of the zDHHC Enzyme in Alzheimer’s Disease
The researchers discovered that the brain enzyme S-acyltransferase (zDHHC) plays a crucial role in the development of Alzheimer’s disease. They found that the post-mortem brains of Alzheimer’s patients contained an excess of this enzyme, which was associated with worse cognitive performance.
A Nasal Spray to Prevent Cognitive Decline
The researchers explored the potential of a nasal spray to inhibit the zDHHC enzyme and prevent cognitive decline. They used an experimental nasal-spray drug called “2-bromopalmitate” to turn off the zDHHC enzyme in genetically modified mice replicating Alzheimer’s disorder. The results were promising, with the treatment successfully stopping neurodegeneration, reducing symptoms, and even extending the animals’ lifespan.
Toward New Treatment Options for Alzheimer’s Disease
While the study’s findings are promising, the researchers acknowledge that more work is needed to develop a safe and effective treatment for Alzheimer’s disease. Thanks to a grant from the Ministry of Health’s 2023 PNRR call, the researchers will continue to explore new therapeutic approaches, including genetic patches and engineered proteins that can interfere with zDHHC enzyme activity.
A New Hope for Alzheimer’s Patients
The study’s findings offer new hope for Alzheimer’s patients and their families. While there is still much work to be done, the discovery of the zDHHC enzyme’s role in Alzheimer’s disease and the potential of a nasal spray to prevent cognitive decline are significant breakthroughs in the fight against this devastating disease.
