A groundbreaking collaboration between Cleveland Clinic and Cornell University introduces PIONEER, a game-changing software that simplifies the identification of crucial protein-protein interactions for drug targeting.
Key Breakthroughs:
- Integrates vast genomic data and physical protein structures.
- Pinpoints interaction points for effective disease treatments.
- Publicly available software and web database.
Advancements in Genomic Research
PIONEER bridges the gap between genomic research and drug discovery, reducing the 10-15 year timeline for developing medications.
Challenges Overcome
- Complex protein interaction networks (interactome).
- Thousands of potential disease-causing interactions.
AI-Driven Solutions
- Integrated data from 100,000 individuals and 16,000 proteins.
- Ranked list of protein-protein interactions for disease treatment.
Impact and Validation
- Validated predictions in lab testing.
- Preliminary research underway for lung and endometrial cancer treatments.
- Predicts cancer survival rates, prognoses, and anti-cancer drug responses.
Reference:
“Protein-protein InteractiOn iNtErfacE pRediction” (PIONEER), Nature Biotechnology, October 24, 2024.
